They often occur as a complication of surgery but can also develop after an injury. In most cases, seromas are harmless and are allowed to heal naturally. Seromas are not related to cancer cells and pose no increased risk or concern. However, they can cause discomfort and lead to a longer hospital stay after surgery.Click to see full answer. Keeping this in consideration, what happens if Seroma is left untreated?Small seromas often resolve on their own, although left untreated, they can calcify, forming hard knots. Seromas can interfere with healing of a surgical site and may require drainage if they are large. An infected seroma can develop into an abscess, indicating the presence of serious infection.Furthermore, how long do Seromas last? Most seromas heal naturally. They are usually reabsorbed into the body within a month, although this can take up to a year. In more severe cases, it can take up to a year for them to be reabsorbed, or they can form a capsule and remain until they are removed surgically. In this way, do Seromas go away? The seroma may go away on its own within a few weeks or months. Your body slowly absorbs the fluid. But if you have a large seroma or if it is causing pain, your healthcare provider may drain it. This is done with a syringe and needle.What does a seroma feel like?In many cases, a seroma will have the appearance of a swollen lump, like a large cyst. It may also be tender or sore when touched. A clear discharge from the surgical incision is common when a seroma is present. You may have an infection if the discharge becomes bloody, changes color, or develops an odor.