Just as there shouldn’t be food in your stomach when you take your hypothyroidism medication, it’s also important to avoid taking any other medication at the same time. Specifically, antacids, calcium, cholesterol drugs, and iron supplements can each interfere with the way the thyroid hormone is absorbed.Click to see full answer. Regarding this, can I take levothyroxine with my other medications?Ideally, levothyroxine should be the only medication taken at bedtime. Just as with morning dosing, it is best to avoid co-administration with other medications such as statins, blood pressure drugs, and metformin.Similarly, what supplements interfere with thyroid medication? Yes. Calcium supplements — or antacids containing calcium — can interfere with the absorption of thyroid hormone replacement medications, such as synthetic thyroid hormones levothyroxine (Synthroid, Unithroid, others) and liothyronine (Cytomel), as well as thyroid extract supplements. Similarly, you may ask, what medications should not be taken with levothyroxine? A number of drugs have been shown to impair the absorption of levothyroxine; these drugs include calcium carbonate, aluminum- containing antacids, sucralfate, iron supplements, cholestyramine, sevelamer, and, possibly, ciprofloxacin, raloxifene, and orlistat.What happens if you take 2 thyroid pills in one day?Taking an extra dose of levothyroxine by accident is unlikely to harm you. Speak to your doctor if: you accidentally take more than 1 extra dose. you get side effects such as a racing heart beat or chest pain – these may not happen straight away – it can be several days before they come on.