Influenza viruses are one of the few RNA viruses to undergo replication and transcription in the nucleus of their host cells. Virus replication begins with entry of the virus into the host cell by a process of engulfment called viropexis or receptor-mediated endocytosis.Click to see full answer. Considering this, how does influenza reproduce?When the influenza virus gets into the body, it moves into the respiratory tract. Once there, it binds to the surface of cells. The virus then opens and releases its genetic information (RNA) into the cell’s nucleus. The virus replicates, or copies itself, and takes over the functions of the cell.Subsequently, question is, where does influenza A replicate? Influenza viruses replicate within the nucleus of the host cell. Hereof, how does influenza replicate its genome? The influenza virus has a negative sense RNA genome. In order to replicate, this means that the virus must first produce positive sense mRNA in order to produce necessary enzymes. The final viral progeny eventually bud from the host cell, ready to infect other cells.How fast does influenza virus replicate? Replication and infectivity The replication cycle of influenza viruses, from the time of entry to the production of new virus, is very quick, with shedding of the first influenza viruses from infected cells occurring after only 6 hours.