Are Rocephin and Cefazolin the Same Thing? Rocephin (ceftriaxone sodium) and cefazolin are cephalosporin antibiotics used to treat many kinds of bacterial infections. Rocephin is also used to treat severe or life-threatening infections such as meningitis. Brand names for cefazolin include Kefzol and Ancef.Click to see full answer. Keeping this in consideration, is cefazolin and cephalexin the same?Among the cephalosporins, cefazolin is the most active against the gram-negative pathogens tested. The relative potency of antibacterial activity of cephalosporins against E. coli in decreasing order is cefazolin, cephaloridine, cephalexin, and cephalothin.Also Know, what kind of antibiotic is cefazolin? Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent infection. This medication is known as a cephalosporin antibiotic. Secondly, what is another name for cefazolin? Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. This medication is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria. Cefazolin is available under the following different brand names: Kefzol and Ancef.What is the difference between Rocephin and ceftriaxone?Rocephin is the brand name of ceftriaxone sodium, a third-generation cephalosporin antibiotic that’s used to fight bacteria in your body. Your doctor may use Rocephin to treat severe or life-threatening forms of bacterial infections such as meningitis.