Fluoroquinolones are antibiotics that are commonly used to treat a variety of illnesses such as respiratory and urinary tract infections. These medicines include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), and ofloxacin (Floxin).Click to see full answer. Beside this, what bacteria do fluoroquinolones cover? Fluoroquinolones are active against the following: Haemophilus influenzae. Moraxella catarrhalis. Mycoplasma sp. Chlamydia sp. Chlamydophila sp. Legionella sp. Enterobacteriaceae. Pseudomonas aeruginosa (particularly ciprofloxacin) One may also ask, how do fluoroquinolones work? Quinolones exert their antibacterial effect by preventing bacterial DNA from unwinding and duplicating. Quinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription. Topoisomerase II is also a target for a variety of quinolone-based drugs. Similarly one may ask, what are quinolone antibiotics used to treat? Quinolones are broad spectrum antibiotics, which means they are effective against a wide range of diseases caused by bacteria. They were approved by the FDA to treat conditions including lower respiratory tract infections, skin infections and urinary tract infections.What is a contraindication to use of a fluoroquinolone?Quinolones are contraindicated if a patient has epilepsy, QT prolongation, pre-existing CNS lesions, or CNS inflammation, or the patient has suffered a stroke. They are best avoided in the athlete population. They are also contraindicated in children due to the risks of damage to the musculoskeletal system.