Medical Definition of Macules Macules: Small circumscribed changes in the color of skin that are neither raised (elevated) nor depressed. Macules are never large. They are basically little spots or blemishes in the skin. The word macule comes from the Latin macula meaning a small spot or blemish.Click to see full answer. Similarly, you may ask, what causes a Macule?Macules can be caused by various conditions that affect the appearance of your skin, resulting in areas of discoloration. Conditions that are likely to cause macules are: vitiligo. moles.Subsequently, question is, are Macules cancerous? Skin Cancer and Macules A macule is not, in and of itself, a sign of skin cancer. While a macule may have an appearance suggestive of cancer, further tests would be needed to confirm or exclude a diagnosis. Melanoma can manifest as a dark spot on the skin or with sudden abnormal changes of a mole. Besides, how is Macule treated? Macules often require no treatment, but laser surgery, cryosurgery, and regular surgical excision of the macule can be performed. Bleaching or peeling agents may help in some instances. In general, the avoidance of sun exposure can limit the appearance of macules on a person’s skin.What does a Macule look like?The most distinctive feature of a maculopapular rash is the pattern of macules and papules. A macule is a small, flat, red area of discoloration, and a papule is a small, red, raised lesion. As a result, a maculopapular rash appears as red bumps against a red background.