Migraine is a chronic neurological condition with episodic exacerbations. Prophylaxis requires daily administration of anti-migraine compounds with potential adverse events or contraindications, and may also interfere with other concurrent conditions and treatments.Click to see full answer. Furthermore, what is the best prophylaxis for migraine?First-line therapies for migraine prophylaxis in adults include propranolol (Inderal), timolol (Blocadren), amitriptyline, divalproex (Depakote), sodium valproate, and topiramate (Topamax).Furthermore, what is the IV treatment for migraine headaches? IV hydration therapy contains fluids, electrolytes, vitamins, and optional anti-nausea and anti-inflammatory add-ons to improve the symptoms of migraines and headaches. Knowing how to tell the difference between a headache and a migraine can help you seek the most effective treatment faster. Also to know is, which drug or class of drugs is a prophylactic therapy for migraine headaches? The major medication groups for prophylactic treatment include β-blockers, anticonvulsant, drugs such as topiramate and valproate, antidepressant drugs, such as amitriptyline and selective serotonin and selective serotonin-norepinephrine reuptake inhibitors (SNRIs), calcium channel antagonists and neurotoxins.Does labetalol help with migraines?Labetalol for prophylactic treatment of intractable migraine during pregnancy. Labetalol was tried successfully in reducing the frequency, duration, and intensity of migraine attacks in a pregnant woman with preeclampsia.