Hormones that work against the action of insulin, raising blood glucose levels in response to hypoglycemia (low blood sugar). The main counterregulatory hormones are glucagon, epinephrine (also known as adrenaline), cortisol, and growth hormone.Click to see full answer. Just so, can hormones cause high blood sugar? Changes in blood sugar level. The hormones estrogen and progesterone affect how your cells respond to insulin. After menopause, changes in your hormone levels can trigger fluctuations in your blood sugar level. If your blood sugar gets out of control, you have a higher risk of diabetes complications.Also, what hormones can cause low blood sugar? Enlargement of beta cells of the pancreas that produce insulin (nesidioblastosis) may result in excessive insulin release, causing hypoglycemia. Hormone deficiencies. Certain disorders of the adrenal glands and the pituitary gland can result in a deficiency of key hormones that regulate glucose production. Herein, what are two major hormones that influence glucose levels? Glucagon, amylin, GIP, GLP-1, epinephrine, cortisol, and growth hormone also affect blood sugar levels.Does cortisol increase blood sugar?Under stressful conditions, cortisol provides the body with glucose by tapping into protein stores via gluconeogenesis in the liver. This energy can help an individual fight or flee a stressor. However, elevated cortisol over the long term consistently produces glucose, leading to increased blood sugar levels.