What is DHFR and why is it important?

Dihydrofolate Reductase (DHFR) is a very important enzyme because it produces cofactors that are necessary for DNA synthesis. THF is an essential cofactor involved in the the transfer of methyl, methylene, and formyl groups from one molecule to another during the production of nucleotides and several amino acids.Click to see full answer. Also to know is, what does dihydrofolate reductase do?Dihydrofolate reductase is a small enzyme that plays a supporting role, but an essential role, in the building of DNA and other processes. It manages the state of folate, a snaky organic molecule that shuttles carbon atoms to enzymes that need them in their reactions.Subsequently, question is, what type of inhibitor is methotrexate? 1 Methotrexate. Methotrexate is a folic acid analogue used to treat a variety of malignant and inflammatory diseases. It is a competitive inhibitor of dihydrofolate reductase, blocking the conversion of dihydrofolate to tetrahydrofolate and inhibiting cellular reproduction. Correspondingly, what does DHFR stand for? Dihydrofolate reductase How does methotrexate interfere with DHFR?It is thought to affect cancer and rheumatoid arthritis by two different pathways. For cancer, methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. The affinity of methotrexate for DHFR is about 1000-fold that of folate.

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