When there is a change in the DNA sequence, called a mutation, the way proteins are made can be affected. Hemophilia is caused by a mutation in the gene responsible for producing clotting factors. The type of hemophilia a person has depends on which gene is disrupted.Click to see full answer. In this manner, what type of mutation is Hemophilia?Hemophilia A is caused by a mutation in the gene for factor VIII, so there is deficiency of this clotting factor. Hemophilia B (also called Christmas disease) results from a deficiency of factor IX due to a mutation in the corresponding gene.Additionally, is Hemophilia A chromosomal mutation? Hemophilia is caused by a mutation or change, in one of the genes, that provides instructions for making the clotting factor proteins needed to form a blood clot. This change or mutation can prevent the clotting protein from working properly or to be missing altogether. These genes are located on the X chromosome. Beside above, is Hemophilia A deletion mutation? Hemophilia A is characterized specifically by a mutation on the factor VIII gene of the X, whereas hemophilia B is caused by a mutation on the factor IX gene of the X chromosome. Deletion mutations are characterized by the deletion of 8-10 consecutive adenosine bases, and gives rise to a moderately severe phenotype.Who carries the gene for hemophilia?The gene that causes hemophilia is passed from parent to child. A mother that carries the gene is called a carrier, and she has a 50% chance of having a son with hemophilia and a 50% chance of having a daughter who is also a carrier.